Preheat your oven to 350°F (175°C) while you prepare your baking sheet lined with parchment paper.
Drizzle each salmon fillet with 1 tablespoon of oil, then season generously with salt, pepper, smoked paprika, and Cajun seasoning on both sides.
Squeeze excess liquid out of your thawed spinach before combining it in a medium bowl with Boursin cheese, jalapeno, crab meat, parmesan cheese, and garlic; season this mixture with salt and pepper according to your taste preferences.
In another medium-sized bowl, toss the peeled shrimp with the remaining tablespoon of oil along with Cajun seasoning, smoked paprika, salt, and pepper.
Carefully cut a slit through the middle of each seasoned salmon fillet without cutting all the way through; stuff them generously with the spinach-crab mixture before layering seasoned shrimp on top.
Transfer your stuffed salmon onto the prepared baking sheet, drizzling melted butter over each piece before baking them in preheated oven for about 15-17 minutes or until cooked through; serve immediately garnished with fresh lemon wedges.